Hair transplantation is performed under local anesthesia and patient does not have the complaint of pain. Considering the hair transplantation can last 2-7 hours, it is reasonable to perform the hair transplantation with local anesthesia. Surgeries with general anesthesia are normally safer than local anesthesia, general anesthesia which lasts 7 hours contains a health risk. The appropriate combination of lidocaine, bupivacaine and adrenaline is sufficient. The addition of sedation especially at the beginning of hair transplant surgery will increase your comfort. The first infiltration is sufficient for 15 minutes of anesthesia effect and you will not feel pain for 4 hours without an additional dose. However, medicines triggering each other might cause heart attacks in the second-dose painkiller administrations, hair transplantation must be performed in the operating room by specialist physicians and under monitorization.